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 »  Home  »  Blogs  »  Broke a tooth? Grow another!
JDI editor


Broke a tooth? Grow another!
Published 08/8/2010

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Dr. George Huang, chair of endodontics at Boston University Henry M. Goldman School of Dental Medicine (GSDM), says the primary teeth and extracted wisdom teeth, we keep throwing away valuable dental stem cells.

"Our team for the first team that we dental stem cells in human embryonic-like cells called induced pluripotent stem cells reprogrammed (iPS cells), the unlimited source of cells for the regeneration of tissue can be found," said Dr. Huang.

So far, scientists have luck creating iPS cells from different cells in mice had slightly, but that has not so simple, in humans, until recently. All three types of human stem cells of the dental team GSDM be tested easier to use than fibroblasts, which previously seemed to make the best way to reprogram human iPS cells.

In a related study, Dr. Huang regenerated two important components of human dental pulp and dentin for the first time in an experimental mouse model. The mouse was used to provide power for human tissue regeneration.

With the help of tissue engineering, researchers looked empty root canal space with pulp-like tissue supplied with enough blood to fill. Dentin-like tissue regrew on the dentinal wall.

"The finding will revolutionize the endodontic and dental clinical practice by helping to preserve teeth," says Dr. Huang. "

The studies, iPS cells from mesenchymal stem cell-like / progenitor cells of the tooth origin and Stem / progenitor cell-mediated de novo regeneration of the pulp reprogrammed to deposit new continuous layer of dentin in an in vivo model to appear in Stem Cells and Development, and Tissue Engineering .